Impact of chronic hepatitis B virus infection on semen parameters of fertile men-Reference-Cited by-同舟云学术

Impact of chronic hepatitis B virus infection on semen parameters of fertile men

Published:2019-08 Issue:8 Volume:14 Page:515-522
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Taha Emad A¹^ORCID,Mekky Mohamed A²^ORCID,Gaber Hisham D¹,Abdel-Gaber Reham M¹,Zahran Asmaa M³,Abd Allah Eman SH⁴,Mohamed Ahmed Q⁵,Hasaballah Ashraf E⁶,Mostafa Taymour⁷,Hetta Helal F⁸⁹

Affiliation:

1. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt

2. Department of Tropical Medicine & Gastroenterology, Assiut University, Assiut, Egypt

3. Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

4. Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

5. Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

6. Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt

7. Department of Andrology and Sexology, Cairo University, Cairo, Egypt

8. Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

9. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA

Abstract

Aim: To investigate the effect of chronic hepatitis B virus (CHB) infection on semen parameters of males with proven fertility. Material & methods: 61 fertile men with CHB infection and a control group of 42 HBV-negative fertile men were assessed for serum and semen HBV viral loads by quantitative real-time PCR, complete semen analysis, hypo-osmotic swelling test, seminal total peroxide, total antioxidant capacity assay and sperm DNA integrity evaluation. Results: CHB men demonstrated significantly lower sperm motility, sperm viability and sperm DNA integrity, seminal total antioxidant capacity assay and significantly increased seminal total peroxide and oxidative stress index compared with controls. CHB cases with positive semen HBV DNA showed a significant increase in seminal total peroxide and oxidative stress index compared with CHB cases with negative semen HBV DNA. Conclusion: CHB has a negative burden on seminal parameters in fertile men.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2019-0039

Reference26 articles.

1. Hepatitis B: The virus and disease

2. Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma

3. Quantitative Analysis of Hepatitis B Virus DNA in Saliva and Semen of Chronically Infected Homosexual Men

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