Evaluation of the immune memory response to routine HBV vaccine in Egyptian patients with Type 1 diabetes-Reference-Cited by-同舟云学术

Evaluation of the immune memory response to routine HBV vaccine in Egyptian patients with Type 1 diabetes

Published:2020-04 Issue:4 Volume:15 Page:215-222
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Hetta Helal F¹²^ORCID,Elsherbiny Nahla M²,Eloseily Esraa M³,Taha Samaher F³,Gad Eman Fathalla³,Soliman Mona M⁴,Mohamed Ghada A⁴,Salama Ragaa H⁵,Elfadl Azza Abo⁶

Affiliation:

1. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA

2. Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

3. Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

4. Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

5. Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

6. Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

Abstract

We aimed to evaluate the immune memory response to HBV vaccine in diabetic patients who had received the full HBV vaccination during infancy and to assess the need for booster doses. Blood samples were collected from children (93 diabetics and 105 controls) and university students (22 diabetics and 20 controls). Anti-HBs titer in serum and after in vitro stimulation of peripheral blood mononuclear cells with HBV vaccine was measured by ELISA. Diabetic groups had significantly lower anti-HBs levels after 10 years of the last HBV vaccine dose. The percentage of diabetic patients having protective anti-HBs titers was significantly lower than controls. In conclusion, diabetic patients had lower immune response to HBV vaccine over time, emphasizing the need for a booster dose.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2019-0121

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1. Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma

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