CD44 targeted delivery of hyaluronic-acid-coated polymeric nanoparticles against colorectal cancer-Reference-Cited by-同舟云学术

CD44 targeted delivery of hyaluronic-acid-coated polymeric nanoparticles against colorectal cancer

Published:2023-10-13 Issue: Volume: Page:
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Phatak Niraj¹^ORCID,Bhattacharya Sankha¹^ORCID,Shah Disha¹^ORCID,Manthalkar Laxmi¹^ORCID,Sreelaya Putrevu¹^ORCID,Jain Arinjay¹^ORCID

Affiliation:

1. School of Pharmacy & Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Deemed-to-Be University, Shirpur, Maharashtra, 425405, India

Abstract

Aim: To develop hyaluronic acid (HA)-coated poly-lactic-co-glycolic acid (PLGA)-polysarcosine (PSAR) coupled sorafenib tosylate (SF) polymeric nanoparticles for targeted colon cancer therapy. Materials & methods: PLGA–PSAR shells were encapsulated with SF via nanoprecipitation. Interactions were examined with transmission electron microscopy, revealing formulation component interactions. Results: The optimized HA-coated polymeric nanoparticles (238.8 nm, -6.1 mV, 68.361% entrapment) displayed enhanced controlled release of SF. These formulations showed superior cytotoxicity against HCT116 cell lines compared with free drug (p < 0.05). In vivo tests on male albino Wistar rats demonstrated improved pharmacokinetics, targeting and biocompatibility. HA-coated PLGA–PSAR-coupled SF polymeric nanoparticles hold potential for effective colorectal therapy. Conclusion: Colon cancer may be precisely targeted by HA-coated PLGA–PSA-coupled SF polymeric nanoparticles.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0145

Reference42 articles.

1. Early colorectal cancer: diagnosis, treatment and survivorship care

2. Molecular Markers and Targets in Melanoma

3. A Literature Review in Immuno-Oncology: Pathophysiological and Clinical Features of Colorectal Cancer and the Role of the Doctor-Patient Interaction

4. Nutritional Treatment of Patients with Colorectal Cancer

5. Systemic review on B-RafV600E mutation as potential therapeutic target for the treatment of cancer

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nanocrystals: Versatile Platform for Traditional Chinese Medicine Delivery;Current Drug Delivery;2024-08-20

2. Nanomedicine for colon-targeted drug delivery: strategies focusing on inflammatory bowel disease and colon cancer;Nanomedicine;2024-06-10

3. Exploring the Potentials of Hyaluronic Acid-coated Polymeric Nanoparticles in Enhanced Cancer Treatment by Precision Drug Delivery, Tackling Drug Resistance, and Reshaping the Tumour Micro Environment;Current Medicinal Chemistry;2024-04-03

4. Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers;Pharmaceutics;2024-03-21

5. Recent progress on polySarcosine as an alternative to PEGylation: Synthesis and biomedical applications;International Journal of Pharmaceutics;2024-03