Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris

Author:

Moore Angela Yen12,Charles Jean Elizze M3,Moore Stephen1

Affiliation:

1. Arlington Research Center, Inc., Arlington, TX 76011, USA

2. Baylor University Medical Center, Dallas, TX 75246, USA

3. Medical City Weatherford Dermatology Residency Program, Weatherford, TX 76086, USA

Abstract

Sarecycline is a novel, narrow-spectrum, once-daily tetracycline-derived oral antibiotic that is FDA-approved in the US to be taken with or without food for moderate-to-severe acne vulgaris for ages 9 years of age and older. Sarecycline possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes, while exhibiting minimal activity against enteric aerobic Gram-negative bacteria. Unlike many acne studies, sarecycline was investigated for chest and back acne. Significant reduction in inflammatory lesions was seen at week 12 at 1.5 mg/kg/day of sarecycline, with statistically significant improvement seen as early as week 3. No reports of phototoxicity, dizziness, pseudotumor cerebri or lupus but 1.2% nausea and 1.2% vaginal candidiasis was reported in the pivotal Phase III studies.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Systematic analysis of the adverse effects of commonly used clinical tetracycline drugs based on the FAERS database;Expert Opinion on Drug Safety;2024-08-19

2. Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies;International Journal of Molecular Sciences;2024-05-13

3. Acne;Rook's Textbook of Dermatology;2024-03-19

4. Tetracyclines: The Old, the New and the Improved - A Short Review;Biomedical and Pharmacology Journal;2023-09-30

5. Bidirectional Interaction between Tetracyclines and Gut Microbiome;Antibiotics;2023-09-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3