Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients-Reference-Cited by-同舟云学术

Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients

Published:2019-04 Issue:6 Volume:11 Page:473-482
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Matsuda Masaya¹,Terada Tetsuya²,Tsujimoto Nau¹,Morie Yuki¹,Ishida Tomoki¹,Takahashi Hiromu¹,Hamaguchi Junpei¹,Tabuchi Yuki¹,Doi Kana¹,Noro Keiki²,Kikuoka Yusuke²,Omura Shuji²,Yoshida Takuya²,Ayani Yusuke²,Suzuki Manabu²,Ichihara Takahiro²,Inaka Yuko²,Inui Takaki²,Kawata Ryo²,Nabe Takeshi¹

Affiliation:

1. Laboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan

2. Department of Otolaryngology, Head & Neck Surgery, Osaka Medical College, Takatsuki, Osaka, Japan

Abstract

Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2018-0170

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