The role of miR-101 in esophageal and gastric cancer-Reference-Cited by-同舟云学术

The role of miR-101 in esophageal and gastric cancer

Published:2021-09 Issue:5 Volume:18 Page:491-499
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Syllaios Athanasios¹^ORCID,Sakellariou Stratigoula²,Garmpis Nikolaos³,Sarlani Eleni²,Damaskos Christos⁴,Apostolou Konstantinos¹,Kykalos Stylianos³,Gazouli Maria⁵,Karavokyros Ioannis¹,Schizas Dimitrios¹^ORCID

Affiliation:

1. First Department of Surgery, National & Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece

2. First Department of Pathology, Medical School, National & Kapodistrian University of Athens, Athens, 11527, Greece

3. Second Propedeutic Department of Surgery, National & Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece

4. N.S. Christeas Laboratory of Experimental Surgery & Surgical Research, Medical School, National & Kapodistrian University of Athens, Athens, 11527, Greece

5. Laboratory of Biology, Medical School, National & Kapodistrian University of Athens, Athens, 11527, Greece

Abstract

miR-101 is downregulated in various types of cancer, leading to the notion that miR-101 acts as a suppressor in cancer cell progression. The comprehensive mechanisms underlying the effects of miR-101 and the exact role of miR-101 dysregulations in esophagogastric tumors have not been fully elucidated. This review aims to summarize all current knowledge on the association between miR-101 expression and esophagogastric malignancies and to clarify the pathogenetic pathways and the possible prognostic and therapeutic role of miR-101 in those cancer types. miR-101 seems to play crucial role in esophageal and gastric cancer biology and tumorigenesis. It could also be a promising novel diagnostic and therapeutic target, as well as it may serve as a significant predictive biomarker in esophagogastric cancer.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme-2021-0024

Reference34 articles.

1. The prognostic value of decreased miR-101 in various cancers: a meta-analysis of 12 studies

2. ERK2-ZEB1-miR-101-1 axis contributes to epithelial–mesenchymal transition and cell migration in cancer

3. MiR-204 down-regulation elicited perturbation of a gene target signature common to human cholangiocarcinoma and gastric cancer

4. miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Expression Patterns and Implications of MALAT1, MANCR, PSMA3-AS1 and miR-101 in Esophageal Adenocarcinoma;International Journal of Molecular Sciences;2023-12-20

2. Functional roles of the lncRNA MALAT1 in glioma;Current Cancer Therapy Reviews;2023-07-20

3. Multiview Convolutional Neural Networks for Predicting the Association between miRNA and Diseases;2023 3rd International Symposium on Computer Technology and Information Science (ISCTIS);2023-07-07

4. The role of miRNAs in liver diseases: Potential therapeutic and clinical applications;Pathology - Research and Practice;2023-03

5. Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents;Pharmacological Research;2023-01