Functional roles of the lncRNA MALAT1 in glioma-Reference-Cited by-同舟云学术

Functional roles of the lncRNA MALAT1 in glioma

Published:2023-07-20 Issue: Volume:19 Page:
ISSN:1573-3947
Container-title:Current Cancer Therapy Reviews
language:en
Short-container-title:CCTR

Author:

Moftakhar Arya¹,Najafi Sajad²³,Anbiyaee Omid⁴,Farzaneh Maryam⁵,Khoshnam Seyed Esmaeil⁶

Affiliation:

1. Department of Biology, Faculty of Basic Sciences and Engineering, University of Gonbad Kavous, Gonbad Kavous, Golestan, Iran

2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4. Cardiovascular Research Center, Nemazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

5. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

6. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Abstract: Gliomas are a group of brain cancers with various clinical and biological features, and they are mostly malignant. Progressions in therapy approaches, comprising radiotherapy, chemotherapy, and surgery, have not been so considerable in the prognosis of glioma cases. Recently, long non-coding RNAs (lncRNAs) have been found with putative regulatory roles in gene expression, epigenetic regulation, neurogenesis, cell cycle, and cellular transportation. The lncRNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is frequently reported to be associated with multiple disorders, such as various types of cancers. Upregulation of MALAT1 is detected in different tumours, including glioma, and functional analyses reveal it affects malignant features of cancer cells like proliferation, migration, invasion and apoptosis. MALAT1 impacts those features by modulating various epigenetic histones, hormones, growth factors, and transcription factors. Therefore, this lncRNA can be regarded as a potent therapeutic target for glioma. In this review, we summarized the functional roles of MALAT1 in glioma.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Oncology,Molecular Medicine