1. Department of Pharmacology & Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.
2. Divisions of Cardiovascular Diseases & Clinical Pharmacology, Departments of Medicine, Molecular Pharmacology & Experimental Therapeutics & Medical Genetics, Mayo Clinic, 200, First Street SW, Rochester, MN 55905, USA.