1. Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, 132 South 10th Street, 1170 Main Philadelphia, PA 19107, USA.
2. Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics and Medical Genetics, Mayo Clinic, 200, First Street SW, Rochester, MN 55905, USA