The validity, stability, and utility of measuring uric acid in saliva

Author:

Riis Jenna L1,Bryce Crystal I12,Matin Marla J3,Stebbins John L3,Kornienko Olga14,Huisstede Lauren van2,Granger Douglas A15678

Affiliation:

1. Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697, USA

2. T. Denny Sanford School of Social & Family Dynamics, Arizona State University, Tempe, AZ 85287, USA

3. Research & Technology Center, Salimetrics, Carlsbad, CA 92008, USA

4. Department of Psychology, George Mason University, Fairfax, VA 22030, USA

5. Department of Population, Family, & Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA

6. Department of Acute & Chronic Care, Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA

7. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

8. Salivary Bioscience Laboratory & Department of Psychology, University of Nebraska, Lincoln, NE 68588, USA

Abstract

Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum–saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum–saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62–66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

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