A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels-Reference-Cited by-同舟云学术

A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels

Published:2019-08-01 Issue:11 Volume:13 Page:931-940
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Rosticci Martina¹,Pervjakova Natalia²³⁴,Kaakinen Marika⁴⁵,Cicero Arrigo F¹,Feufer Arne P⁶,Marullo Letizia⁷,Mägi Reedik²,Fischer Krista²,Jiang Longda⁴,D'Addato Sergio¹,Rizzoli Elisabetta¹,Massimo Gianmichele⁸,Giovannini Marina¹,Angelini Sabrina⁸,Hrelia Patrizia⁸,Scapoli Chiara⁷,Borghi Claudio¹,Prokopenko Inga⁴

Affiliation:

1. Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy

2. Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia

3. Department of Biotechnology, Institute of Molecular & Cell Biology, University of Tartu, Tartu, Estonia

4. Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK

5. Pharmacology & Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK

6. Institute of Bioinformatics & Systems Biology, Helmholtz Zentrum München, München, Germany

7. Department of Life Sciences & Biotechnology, University of Ferrara, Ferrara, Italy

8. Department of Pharmacy & Biotechnology, Alma Mater Studiorum University of Bologna, Italy

Abstract

Aim: The aim of the study was to explore the effects of variants at HMGCR-KIF6loci on a range of cardio-metabolic phenotypes. Methods: We analyzed the range of variants within Genetics in Brisighella Health Study and KIF6 genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu. Results: We defined directly the effects of rs3846662:C>A at HMGCR on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in KIF6 gene did not reveal any associations with cardiometabolic phenotypes. Conclusion: This study highlights effect of HMGCR locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2017-0431

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