Targeting LIN28: a new hope in prostate cancer theranostics

Author:

Shrivastava Garima1,Aljabali Alaa AA2ORCID,Shahcheraghi Seyed Hossein3,Lotfi Marzieh3,Shastri Madhur D4,Shukla Shakti D5,Chellappan Dinesh K6ORCID,Jha Niraj Kumar7,Anand Krishnan8,Dureja Harish9,Pabari Ritesh M10,Mishra Vijay11ORCID,Almutary Abdulmajeed G12,Alnuqaydan Abdullah M12,Charbe Nitin13,Prasher Parteek14,Negi Poonam15,Goyal Rohit15,Dua Kamal16ORCID,Gupta Gaurav17,Serrano-Aroca Ángel18,Bahar Bojlul19,Barh Debmalya20,Panda Pritam Kumar21,Takayama Kazuo22,Lundstorm Kenneth23,McCarron Paul24,Bakshi Hamid24ORCID,Tambuwala Murtaza M24ORCID

Affiliation:

1. Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India

2. Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid-Jordan

3. Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4. School of Pharmacy & Pharmacology, University of Tasmania, Hobart, Australia

5. Priority Research Centre for Healthy Lungs, School of Medicine & Public Health, The University of Newcastle, Callaghan, Australia

6. Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

7. Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India

8. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences & National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa

9. Department of Chemistry, School of Science, GITAM University, Hyderabad 502329, India

10. RCSI, University of Medicine & Health Sciences, Dublin, Ireland

11. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

12. Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia

13. Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 340, Región Metropolitana, Chile

14. Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India

15. School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173229, India

16. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Australia

17. School of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, India

18. Biomaterials & Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia, San Vicente Mártir, Valencia 46001, Spain

19. International Institute of Nutritional Sciences & Food Safety Studies, University of Central Lancashire, Preston, United Kingdom

20. Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

21. Condensed Matter Theory Group, Materials Theory Division, Department of Physics & Astronomy, Uppsala University, Uppsala 75120, Sweden

22. Center for IPS Cell Research & Application, Kyoto University, Kyoto 606-8397, Japan

23. PanTherapeutics, Lutry CH1095, Switzerland

24. School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, UK

Abstract

The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference41 articles.

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