Vismodegib: a promising drug in the treatment of basal cell carcinomas

Author:

Dirix Luc1,Rutten Annemie2

Affiliation:

1. Sint-Augustinus Hospital, Oosterveldlaan 24, Antwerp, Belgium.

2. Sint-Augustinus Hospital, Oosterveldlaan 24, Antwerp, Belgium

Abstract

Hedgehog pathway signaling is important for embryonic development; however, inappropriate reactivation of this pathway in adults has been linked to several forms of cancer. Vismodegib (Erivedge™), a first-in-class hedgehog pathway inhibitor, blocks the pathway by inhibiting the activity of the signaling protein SMO. Preclinical studies have provided promising indications of potential tumor-reducing activity in several cancers. Thus far, clinical pharmacology and Phase I studies have demonstrated the unique pharmacokinetic profile of vismodegib, its efficacy in certain types of tumors and a generally tolerable adverse-event profile. A pivotal Phase II clinical trial confirmed the favorable benefit:risk profile of vismodegib in advanced basal cell carcinoma.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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