Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update-Reference-Cited by-同舟云学术

Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update

Published:2016-09 Issue:18 Volume:12 Page:2095-2105
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Chen Leon¹,Silapunt Sirunya¹,Migden Michael R¹²

Affiliation:

1. Department of Dermatology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA

2. Departments of Dermatology & Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract

The Hedgehog inhibitors are promising alternative for patients with advanced basal cell carcinoma that are not amenable to radiotherapy or surgery. Sonidegib, also known as LDE225, is an orally available SMO antagonist that was recently approved by the US FDA for the treatment of patients with locally advanced basal cell carcinoma. This article will provide an overview of the pharmacology and pharmacokinetics of sonidegib and in-depth analysis of the BOLT trial with additional data from the 12-month update. The present challenges associated with Hedgehog inhibitors will also be discussed.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2016-0118

Reference35 articles.

1. Non-melanoma skin cancer

2. Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations

3. Tumor Recurrence 5 Years after Treatment of Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

4. Do basal cell carcinomas recur after complete conventional surgical excision?

5. The Genetics of Melanoma: Recent Advances

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