A good marker does not mean a good target for clinical trials in Alzheimer's disease: the amyloid hypothesis questioned
Author:
Affiliation:
1. Department of Neurology, Hospital Universitario Miguel Servet, Aragon, Spain
2. Department of Psychiatry, University of Zaragoza, Aragon, Spain
Publisher
Future Medicine Ltd
Subject
Neurology (clinical)
Link
https://www.futuremedicine.com/doi/pdf/10.2217/nmt-2019-0006
Reference19 articles.
1. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic
2. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
3. Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease
4. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
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