Affiliation:
1. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, T.R. North Cyprus, via Mersin 10, Turkey
Abstract
:
The strategies to combat Alzheimer’s Disease (AD) have been changing with respect to the
failures of many drug candidates assessed in clinical studies, the complex pathophysiology of AD,
and the limitations of the current drugs employed. So far, none of the targets, either validated or nonvalidated, have been shown to be purely causative in the generation and development of AD. Considering the progressive and the neurodegenerative characteristics of the disease, the main strategy has
been based on the design of molecules capable of showing activity on more than one receptor, and it
is defined as multi-target ligand design strategy. The hybrid molecule concept is an outcome of this
approach. Donepezil, as one of the currently employed drugs for AD therapy, has also been utilized in
hybrid drug design studies. This review has aimed to present the promising donepezil-like hybrid
molecules introduced in the recent period. Particularly, multi-target ligands with additional activities
concomitant to cholinesterase inhibition are preferred.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
6 articles.
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