Molecular biology and pathogenesis of Crimean–Congo hemorrhagic fever virus

Abstract

Over the last several years, we have experienced an increase of large outbreaks of Crimean–Congo hemorrhagic fever virus in European countries and neighboring areas. This disease poses a great threat to public health owing to its high mortality rate, modes of transmission and geographical distribution. Clinical symptoms of infection commonly include hemorrhage, myalgia and fever. The complexity of the technical and facility requirements, in combination with the sporadic outbreaks and consequent lack of clinical specimens has resulted in very limited research of Crimean–Congo hemorrhagic fever virus. To date, there is no vaccine available and a selective antiviral drug for the treatment of the disease is not expected in the near future. Here, we review the most recent findings on the Crimean–Congo hemorrhagic fever virus molecular biology and pathogenesis, including aspects of virus–host cell interactions.