1. Thomas Jefferson University, Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.
2. Mayo Clinic, Divisions of Cardiovascular Diseases & Clinical Pharmacology, Departments of Medicine, Molecular Pharmacology & Experimental Therapeutics and Medical Genetics, Mayo Clinic, 200 First Street, S.W. Rochester, MN 55905, USA.