Inorganic nanoparticle biomolecular corona: formation, evolution and biological impact

Abstract

Physicochemical changes to inorganic nanoparticles (NPs) in biological environments determine their impact. Blood, lymph, mucus, complete cell culture media and other biological fluids contain a large amount and variety of different molecules. NPs dispersed in these fluids are sensitive to such environments. One of the most significant alterations is the formation of the NP–protein corona (PC) as a result of the adsorption of proteins onto the inorganic surface. This process is currently gaining attention in the field of inorganic NPs since this spontaneous coating gives a biological identity to the composite NP–PC and determines the interactions between the NP and the host in living systems. Therefore, knowledge of NP–PC formation is crucial for understanding the evolution, biodistribution and reactivity of NPs inside organisms and, therefore, for the safe design of engineered NPs.