Ribavirin: pharmacology, multiple modes of action and possible future perspectives-Reference-Cited by-同舟云学术

Ribavirin: pharmacology, multiple modes of action and possible future perspectives

Published:2019-03 Issue:3 Volume:14 Page:153-160
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Nyström Kristina¹,Waldenström Jesper¹,Tang Ka-Wei¹,Lagging Martin¹

Affiliation:

1. Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Västra Götaland Region, Sweden

Abstract

Ribavirin is a unique guanosine analog with broad-spectrum activity against many RNA and DNA viruses. In addition to its mutational properties, ribavirin exerts extensive perturbation of cellular and viral gene expression. Furthermore, recent advances indicate that the impact of ribavirin on divergent cellular and viral pathways may be concentration dependent. This review aims at providing an overview of the pharmacology and multiple modes of action of ribavirin as well as pointing to possible novel future uses.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2018-0166

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