Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery

Author:

Thong Phan Quoc12,Thu Huong Le Thi13ORCID,Tu Nguyen Dac4,My Nhung Hoang Thi4ORCID,Khanh Lam5,Manh Do Hung1ORCID,Nam Pham Hong16ORCID,Phuc Nguyen Xuan17ORCID,Alonso Javier89ORCID,Qiao Ju10,Sridhar Srinivas10,Thu Ha Phuong1ORCID,Phan Manh Huong9ORCID,Kim Thanh Nguyen Thi1112ORCID

Affiliation:

1. Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 11355, Vietnam

2. University of Khanh Hoa, 1 Nguyen Chanh, Nha Trang, 57100, Vietnam

3. Faculty of Natural Resources and Environment, Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, 12400, Vietnam

4. Hanoi University of Science, Vietnam National University, 334 Nguyen Trai, Hanoi, 11400, Vietnam

5. 108 Military Central Hospital, 1 Tran Hung Dao, Hanoi, 11000, Vietnam

6. Graduate University of Science & Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 12400, Vietnam

7. Duy Tan University, 3 Quang Trung, Danang, 50300, Vietnam

8. Department of CITIMAC, Universidad de Cantabria, Santander, 39005, Spain

9. Department of Physics, University of South Florida, Tampa, FL 33620, USA

10. Department of Physics, Bioengineering & Chemical Engineering, Northeastern University, Boston, MA 02115, USA

11. Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, WC1E 6BT, London

12. UCL Healthcare Biomagnetics & Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK

Abstract

Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. Methods: This study fabricated novel trifunctional MNPs of Fe3O4@PLA-PEG for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity ( r2 = 364.75 mM-1s-1). The in vivo study confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential for drug release, cancer treatment monitoring and therapy.

Funder

Engineering and Physical Sciences Research Council

Asian Office of Aerospace Research and Development

Spanish Government

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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