Stem cells for the treatment of glioblastoma: a 20-year perspective

Author:

Calinescu Anda-Alexandra1ORCID,Kauss McKenzie C12,Sultan Zain13,Al-Holou Wajd N1ORCID,O’Shea Sue K4

Affiliation:

1. Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA

2. College of Literature Science & Arts, University of Michigan, Ann Arbor, MI 48109, USA

3. College of Engineering, University of Michigan, Ann Arbor, MI 48109, USA

4. Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Abstract

Glioblastoma, the deadliest form of primary brain tumor, remains a disease without cure. Treatment resistance is in large part attributed to limitations in the delivery and distribution of therapeutic agents. Over the last 20 years, numerous preclinical studies have demonstrated the feasibility and efficacy of stem cells as antiglioma agents, leading to the development of trials to test these therapies in the clinic. In this review we present and analyze these studies, discuss mechanisms underlying their beneficial effect and highlight experimental progress, limitations and the emergence of promising new therapeutic avenues. We hope to increase awareness of the advantages brought by stem cells for the treatment of glioblastoma and inspire further studies that will lead to accelerated implementation of effective therapies.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Future Medicine Ltd

Subject

General Medicine

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