A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19-Reference-Cited by-同舟云学术

A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19

Published:2022-02 Issue:2 Volume:17 Page:119-139
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Makoah Nigel A¹^ORCID,Tipih Thomas¹^ORCID,Litabe Matefo M¹^ORCID,Brink Mareza²^ORCID,Sempa Joseph B³⁴^ORCID,Goedhals Dominique¹⁵^ORCID,Burt Felicity J¹⁵^ORCID

Affiliation:

1. Division of Virology, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, Free State, South Africa

2. Free State Department of Health, Bloemfontein, 9301, Free State, South Africa

3. Department of Biostatistics, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, Free State, South Africa

4. DST-NRF Centre of Excellence in Epidemiological Modelling & Analysis (SACEMA), Stellenbosch University, Stellenbosch, 7600, Western Cape, South Africa

5. Division of Virology, National Health Laboratory Service, Bloemfontein, 9301, Free State, South Africa

Abstract

Aim: The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials & methods: A systematic review and meta-analysis of 58 publications were performed using data obtained from Academic Search Ultimate, Africa-wide, Scopus, Web of Science and MEDLINE. Results: We found that the highest pooled sensitivities were obtained with ELISA immunoglobulin (Ig)M and IgG and chemiluminescence immunoassay IgM tests. Conclusion: Serological tests have low sensitivity within the first week of symptom onset and cannot replace nucleic acid amplification tests. However, serological assays can be used to support nucleic acid amplification tests.

Funder

National Research Foundation

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2021-0211

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