Association between human herpesvirus-6 and primary brain tumors: a systematic review and meta-analysis-Reference-Cited by-同舟云学术

Association between human herpesvirus-6 and primary brain tumors: a systematic review and meta-analysis

Published:2022-05 Issue:5 Volume:17 Page:305-314
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Ghorbani Saied¹^ORCID,Letafati Arash²,Khatami Alireza¹,Farzi Rana³,Shabani Soha⁴,Moradi Pouya⁵,Tambrchi Vahid¹,Saadati Hassan⁶,Papizadeh Saher⁷,Rad Mona Vasei⁸,Tabatabaei Raheleh⁹,Bahadory Saeed¹⁰,Tavakoli Ahmad¹¹¹^ORCID,Bokharaei-Salim Farah¹^ORCID,Monavari Seyed Hamidreza¹,Fatemipour Maryam¹,Hoseini Mahdieh¹,Kiani Seyed Jalal¹^ORCID

Affiliation:

1. Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

2. Department of Virology, School of public health, Tehran University of Medical Science, Tehran, Iran

3. Department of Virology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran

4. Faculty of veterinary medicine, Azad University, Research Sciences Branch, Tehran, Iran

5. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

6. Department of Epidemiology & Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

7. Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran

8. Paramedicine Department, Islamic Azad University, Babol Medical Sciences Branch, Babol, Mazandaran, Iran

9. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

10. Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

11. Research Center of Pediatric Infectious Diseases, Institute of Immunology & Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Abstract

Aim: The present study aimed to find out the prevalence and any possible association between human herpesvirus (HHV-6) and primary brain tumors. Materials & methods: The systematic literature search was performed by finding related articles from major databases. Analysis was performed by comprehensive meta-analysis software. Results: A total of 13 (25 datasets) articles were included in the study, seven (15 datasets) of which were case/control and the rest (10 datasets) were cross-sectional studies. The pooled prevalence of HHV-6 among primary brain cancer patients was 29% (95% CI: 24–33%; I2 = 97.89%). An association was found between HHV-6 and primary brain cancer (summary odds ratio: 3.77% [95% CI: 2.59–5.49%; I2 = 19.0%]). Conclusion: Our analysis demonstrated that HHV-6 is associated with primary brain cancer. Reactivation of the virus could be triggered by the tumor, therefore, we cannot be certain that the virus appeared before the cancer development.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2021-0096

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