Stereotactic body radiation therapy for prostate cancer

Author:

Ishiyama Hiromichi12,Teh Bin S,Lo Simon S3,Mathews Thomas1,Blanco Angel I1,Amato Robert J4,Ellis Rodney J3,Mayr Nina A5,Paulino Arnold C1,Xu Bo1,Butler E Brian1

Affiliation:

1. Department of Radiation Oncology, The Methodist Hospital & Research Institute, Houston, TX, USA; The Methodist Hospital Cancer Center, 6565 Fannin, Ste#DB1–077, Houston, Texas 77030, USA

2. Department of Radiology & Radiation Oncology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

3. Department of Radiation Oncology, Case Western Reserve University, UH Seidman Cancer Center, Cleveland, OH 44106, USA

4. Division of Oncology, University of Texas Health Science Center, Houston, TX 77030, USA

5. Department of Radiation Oncology, Arthur G James Cancer Hospital, Columbus, OH 43210, USA

Abstract

Stereotactic body radiation therapy (SBRT) is a promising treatment option for prostate cancer. Hypofractionation regimens, such as SBRT, may be more advantageous compared with conventional regimens because low α:β ratio of prostate cancer has high sensitivity to dose per fraction. In addition, a smaller and tighter margin with SBRT is expected to provide a low toxicity rate without reducing tumor control. The purpose of this article is to examine radiobiological, technical and clinical aspects of SBRT for prostate cancer.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference54 articles.

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5. TehBS, Gao Y, Wang Xet al.In vitroandin vivoefficacy of ablative hypfractionation radiation/stereotactic body radiation therapy (SBRT) for human prostate cancer.Proc. Radiological Soc. North America Annual Meeting. Abstract SSA22–01, (2008).

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