Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin-Reference-Cited by-同舟云学术

Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin

Published:2020-11 Issue:17 Volume:15 Page:1611-1619
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

AV Sá Lívia G do¹²^ORCID,Silva Cecília R da¹²,de A Neto João B¹²³,Cândido Thiago M¹²,de Oliveira Leilson C¹²,do Nascimento Francisca BSA¹²,Barroso Fátima DD¹²,da Silva Lisandra J¹²,de Mesquita Jacó RL⁴,de Moraes Manoel O²,Cavalcanti Bruno C²,Júnior Hélio VN¹²

Affiliation:

1. Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

2. Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

3. University Center Christus, Fortaleza, CE, Brazil

4. St. Joseph Hospital for Infectious Diseases, Fortaleza, CE, Brazil

Abstract

Aim: The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. Materials & methods: The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used. Results: MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis. Conclusion: Etomidate showed antibacterial activity against MRSA.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0078

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