Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin-Reference-Cited by-同舟云学术

Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin

Published:2020-11 Issue:17 Volume:15 Page:1611-1619
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

AV Sá Lívia G do¹²^ORCID,Silva Cecília R da¹²,de A Neto João B¹²³,Cândido Thiago M¹²,de Oliveira Leilson C¹²,do Nascimento Francisca BSA¹²,Barroso Fátima DD¹²,da Silva Lisandra J¹²,de Mesquita Jacó RL⁴,de Moraes Manoel O²,Cavalcanti Bruno C²,Júnior Hélio VN¹²

Affiliation:

1. Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

2. Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

3. University Center Christus, Fortaleza, CE, Brazil

4. St. Joseph Hospital for Infectious Diseases, Fortaleza, CE, Brazil

Abstract

Aim: The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. Materials & methods: The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used. Results: MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. Etomidate also showed activity against MRSA biofilm at concentration of 250 μg/ml. Cytometric analysis revealed that the cells treated with etomidate leading to cell death, probably by apoptosis. Conclusion: Etomidate showed antibacterial activity against MRSA.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0078

Reference44 articles.

1. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children

2. World Health Organization. WHO publishes list of bacteria for which new antibiotics are urgently needed. http://www.who.int/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed

3. Centers for Disease Control and Prevention. Staph infections can kill (2019). http://www.cdc.gov/vitalsigns/staph/index.html

4. The role of biofilms in persistent infections and factors involved inica-independent biofilm development and gene regulation inStaphylococcus aureus

5. Multistate Point-Prevalence Survey of Health Care–Associated Infections

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Promising activity of etomidate against mixed biofilms of fluconazole-resistant Candida albicans and methicillin-resistant Staphylococcus aureus;Journal of Medical Microbiology;2024-02-22

2. Antimicrobial Activity of Hydralazine Against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus Aureus;Future Microbiology;2024-01

3. Combining the dual antibacterial and regenerative activities of platelet-rich plasma with β-lactams to mitigate MRSA-infected skin wounds;Biomedicine & Pharmacotherapy;2023-09

4. Antibacterial activity of paroxetine againstStaphylococcus aureusand possible mechanisms of action;Future Microbiology;2023-05

5. Activity of amlodipine againstStaphylococcus aureus: association with oxacillin and mechanism of action;Future Microbiology;2023-05