Activity of amlodipine against<i>Staphylococcus aureus</i>: association with oxacillin and mechanism of action-Reference-Cited by-同舟云学术

Activity of amlodipine againstStaphylococcus aureus: association with oxacillin and mechanism of action

Published:2023-05 Issue:8 Volume:18 Page:505-519
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Barbosa Amanda D¹²^ORCID,Sá Lívia GAV¹²³^ORCID,Neto João BA¹²³^ORCID,Rodrigues Daniel S¹²^ORCID,Cabral Vitória PF¹²^ORCID,Moreira Lara EA¹²^ORCID,Aguiar Igor G¹²,Santos Hélcio S⁴^ORCID,Cavalcanti Bruno C²^ORCID,Marinho Emmanuel S⁵^ORCID,Silva Jacilene⁵,Magalhães Hemerson IF⁶^ORCID,Moraes Manoel O²,Júnior Hélio VN¹²^ORCID,Silva Cecília R¹²^ORCID

Affiliation:

1. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Laboratório de Bioprospecção em Moléculas Antimicrobianas (LABIMAN), Universidade Federal do Ceará, Fortaleza, Ceará, Brasil, CEP: 60.430-370 Se você possui [Consulta-Q4: (PROD) para

2. Centro de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil, CEP: 60.430-275.

3. Centro Universitário Christus, Fortaleza, Ceará, Brasil

4. Centro de Ciências Exatas e Tecnologia, Universidade Estadual do Vale do Acaraú, Sobral, Ceará, Brasil

5. Departamento de Química, Grupo de Química Teórica e Eletroquímica (GQTE), Universidade Estadual do Ceará, Limoeiro do Norte, Ceará, Brasil

6. Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, PB, Brasil

Abstract

Aim: This study was designed to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. Materials & methods: The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques. Results: Amlodipine showed activity against S. aureus between 64 and 128 μg/ml, in addition to showing synergism in approximately 58% of the strains used. Amlodipine also showed good activity against forming and mature biofilms. The possible mechanism of action may be attributed to its ability to lead to cell death. Conclusion: Amlodipine has antibacterial activity against S. aureus.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2022-0230

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