Prognostic value of lymphocyte–C-reactive protein ratio in patients with liver cancer: a meta-analysis

Author:

Shao Yong-jie1,Yu Guo-dong2,Zhang Xi3ORCID,Ran Yu-ge3ORCID,Li Jing-hua2

Affiliation:

1. Department of Radiology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, 518067, China

2. Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, 071000, China

3. Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, 071000, China

Abstract

Background: The impact of lymphocyte–C-reactive protein ratio (LCR) on clinical outcomes has been reported in liver cancer such as hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), but the results remain inconsistent. Methods: We searched PubMed, Scopus, Web of Science, Embase and Cochrane Library databases for relevant studies evaluating the association of LCR with survival outcomes and clinicopathological parameters. Results: Eight studies with 4316 patients were included in this meta-analysis. Low LCR was significantly associated with poor overall survival, disease-free survival/relapse-free survival and disease progression clinicopathological parameters in patients with HCC or ICC. Conclusion: Low pretreatment LCR was an adverse prognostic indicator in patients with HCC or ICC. In addition, it was correlated with clinicopathological parameters indicating a higher stage of malignancy.

Funder

The Government-funded Clinical Talent Training Project

Practical Teaching Reform and Research Project of Affiliated Hospital of Hebei University

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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