Correlation among maternal risk factors, gene methylation and disease severity in females with autism spectrum disorder-Reference-Cited by-同舟云学术

Correlation among maternal risk factors, gene methylation and disease severity in females with autism spectrum disorder

Published:2022-02 Issue:4 Volume:14 Page:175-185
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Gallo Roberta¹,Stoccoro Andrea¹^ORCID,Cagiano Romina²,Nicolì Vanessa¹,Ricciardi Rosanna¹,Tancredi Raffaella²,Trovato Rosanna²,Santorelli Filippo Maria²,Calderoni Sara²³,Muratori Filippo²³,Migliore Lucia¹,Coppedè Fabio¹^ORCID

Affiliation:

1. Department of Translational Research & of New Surgical & Medical Technologies, University of Pisa, Via Roma 55, Pisa, 56126, Italy

2. IRCCS Stella Maris Foundation, Calambrone, Pisa, 56128, Italy

3. Department of Clinical & Experimental Medicine, University of Pisa, Via Roma 55, Pisa, 56126, Italy

Abstract

Aim: To detect early-life environmental factors leading to DNA methylation changes of autism spectrum disorder (ASD)-related genes in young ASD females and reveal epigenetic biomarkers of disease severity. Materials & methods: We investigated blood methylation levels of MECP2, OXTR, BDNF, RELN, BCL2, EN2 and HTR1A genes in 42 ASD females. Results: Maternal gestational weight gain correlated with BDNF methylation levels (Bonferroni-corrected p = 0.034), and lack of folic acid supplementation at periconception resulted in higher disease severity in the ASD children (Bonferroni-corrected p = 0.048). RELN methylation levels were inversely correlated with disease severity (Bonferroni corrected p = 0.042). Conclusion: The present study revealed gene–environment interactions and potential epigenetic biomarkers of disease severity in ASD females.

Funder

University of Pisa

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2021-0494

Reference67 articles.

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