Dysregulated expression of miRNAs in immune thrombocytopenia-Reference-Cited by-同舟云学术

Dysregulated expression of miRNAs in immune thrombocytopenia

Published:2021-08 Issue:16 Volume:13 Page:1317-1327
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Jafarzadeh Abdollah¹²,Marzban Havva³,Nemati Maryam⁴⁵,Jafarzadeh Sara⁶,Mahjoubin-Tehran Maryam⁷,Hamblin Michael R⁸,Mirzaei Hamed⁹¹⁰^ORCID,Mirzaei Hamid Reza¹¹^ORCID

Affiliation:

1. Department of Immunology, School of Medicine, Kerman University of Medical Sciences, 76169-13555, Kerman, Iran

2. Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, 7718175911, Rafsanjan, Iran

3. Department of Pathology & Experimental Animals, Razi Vaccine & Serum Research Institute, Agricultural Research, Education & Extension Organization (AREEO), 31975/148 Karaj, Iran

4. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, 77181/75911, Rafsanjan, Iran

5. Department of Hematology & Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, 76169-13555, Kerman, Iran

6. Student Research Committee, School of Medicine, Kerman University of Medical Sciences, 76169-13555, Kerman, Iran

7. Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, 13131– 99137, Mashhad, Iran

8. Laser Research Centre, Faculty of Health Science, University of Johannesburg, 2028 Doornfontein, South Africa

9. Research Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, 87159-88141, Kashan, Iran

10. Student Research Committee, Kashan University of Medical Sciences, 87159-88141, Kashan, Iran

11. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, 1417613151, Tehran, Iran

Abstract

In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2021-0092

Reference87 articles.

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3. The ITP syndrome: pathogenic and clinical diversity

4. Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia

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