miRNA-21, an Important Regulator of Autoimmune Diseases

Author:

Tofigh Roghayeh1,Safaralizadeh Reza1,Hosseinpourfeizi Mohammadali1,Hemmat Nima2,Baradaran Behzad2

Affiliation:

1. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Abstract: miRNA-21 is regarded as both an abundant and highly conserved member of the microRNA (miRNA) family. It is expressed in virtually every cell and is responsible for critical regulatory actions that are important in health and disease. This microRNA has been shown to potentially have a role in the pathogenesis of several immune-related disorders, including autoimmune diseases, such as Multiple sclerosis and systemic lupus erythematosus, as two prominent examples of diseases that might be involved. In the current research, we looked at the role of miRNA-21, regarded as one of the most significant pathogenic miRNAs with a role in the development of autoimmune illness.

Publisher

Bentham Science Publishers Ltd.

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