Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer-Reference-Cited by-同舟云学术

Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer

Published:2011-06 Issue:6 Volume:7 Page:727-736
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Guppy Amy¹,Jamal-Hanjani Mariam²,Pickering Lisa²

Affiliation:

1. Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, UK

2. St George’s Hospital Healthcare NHS Trust, Blackshaw Road, London SW17 9QT, UK.

Abstract

Metformin is an orally available, biguanide derivative that is widely used in the treatment of Type 2 diabetes. Recent preclinical data have demonstrated that it can also act as an anticancer agent by activation of AMPK and subsequent inhibition of mTOR. Metformin is currently being investigated in several Phase II/III clinical trials. This article will review the current evidence for its mechanism of action, efficacy in preclinical and clinical models, and toxicity. Ongoing and planned studies evaluating the impact of metformin on breast cancer outcomes are also discussed.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.11.49

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