Integrating pharmacogenomic testing into paired germline and somatic genomic testing in patients with cancer

Author:

Seligson Nathan D12ORCID,Kolesar Jill M34ORCID,Alam Benish5,Baker Laura6,Lamba Jatinder K7ORCID,Fridley Brooke L8ORCID,Salahudeen Ameen A910ORCID,Hertz Daniel L5ORCID,Hicks J Kevin11ORCID

Affiliation:

1. Department of Pharmacotherapy & Translational Research, The University of Florida, Jacksonville, FL 32209, USA

2. Center for Pharmacogenomics & Translational Research, Nemours Children's Health, Jacksonville, FL 32207, USA

3. Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA

4. Department of Pharmacy Practice & Science, University of Kentucky, Lexington, KY 40536, USA

5. Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA

6. Nemours Center for Cancer & Blood Disorders, Nemours Children's Health, Wilmington, DE 19803, USA

7. Department of Pharmacotherapy & Translational Research, The University of Florida, Gainesville, FL 32611, USA

8. Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA

9. Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA

10. Tempus Labs Inc., Chicago, IL 60654, USA

11. Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA

Abstract

Precision medicine has revolutionized clinical care for patients with cancer through the development of targeted therapy, identification of inherited cancer predisposition syndromes and the use of pharmacogenetics to optimize pharmacotherapy for anticancer drugs and supportive care medications. While germline (patient) and somatic (tumor) genomic testing have evolved separately, recent interest in paired germline/somatic testing has led to an increase in integrated genomic testing workflows. However, paired germline/somatic testing has generally lacked the incorporation of germline pharmacogenomics. Integrating pharmacogenomics into paired germline/somatic genomic testing would be an efficient method for increasing access to pharmacogenomic testing. In this perspective, the authors argue for the benefits of implementing a comprehensive approach integrating somatic and germline testing that is inclusive of pharmacogenomics in clinical practice.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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