Association of <i>OPRK1</i> rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes-Reference-Cited by-同舟云学术

Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes

Published:2023-04 Issue:6 Volume:24 Page:325-334
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Özkan-Kotiloğlu Selin¹^ORCID,Kaya-Akyüzlü Dilek²^ORCID,Yalçın-Şahiner Şafak³⁴^ORCID,Ayaz Nagihan⁵^ORCID

Affiliation:

1. Kırşehir Ahi Evran University, Faculty of Science & Art, Department of Molecular Biology & Genetics, Kırşehir, Türkiye

2. Ankara University, Institute of Forensic Sciences, Ankara, 06590, Türkiye

3. Ankara Training & Research Hospital AMATEM Clinic, Ankara, 06374, Türkiye

4. Kütahya Health Sciences University, Faculty of Medicine, Department of Mental Health & Diseases, Kütahya, 43020,Türkiye

5. Ankara City Hospital, Ankara, 06800, Türkiye

Abstract

Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR–RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. Results: OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD. Conclusion: Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes.

Funder

Ankara University Scientific Research Projects Coordination Unit

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2023-0037

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