Current status of opioid addiction treatment and related preclinical research

Author:

Kreek M. J.1ORCID,Reed B.1,Butelman E. R.1ORCID

Affiliation:

1. Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY, USA.

Abstract

Two effective treatments for opioid addiction, methadone and buprenorphine-naloxone maintenance, should be widely implemented.

Funder

National Institute on Drug Abuse

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Robertson Therapeutic Discovery Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference116 articles.

1. Drug and opioid-involved overdose deaths—United States, 2013–2017;Scholl L.;MMWR Morb. Mortal. Wkly Rep.,2019

2. U.N.O.D.C. United Nations Office of Drugs and Crime (2017).

3. Incidence, reversal, and prevention of opioid-induced respiratory depression;Dahan A.;Anesthesiology,2010

4. Mu opioid receptor: A gateway to drug addiction;Contet C.;Curr. Opin. Neurobiol.,2004

5. Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances;Kandel D. B.;Drug Alcohol Depend.,2017

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