Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population-Reference-Cited by-同舟云学术

Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population

Published:2020-04 Issue:6 Volume:14 Page:441-450
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Shen Can¹²,Zhong Yue¹²,Huang Xingming²³,Wang Yanyun²,Peng Ying¹,Li Kai¹²,Zhou Bin²,Zhang Lin²,Rao Li¹

Affiliation:

1. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China

2. Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China

3. Department of Pathology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, China

Abstract

Aim: The present study aimed to investigate the role of TAB2 gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. Materials & methods: A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan–Meier curves and Cox regression analysis. Results: G carriers (AG/GG) and AG genotype of rs237028 had a higher DCM susceptibility as well as a worse DCM prognosis. Additionally, C carriers (CT/CC) of rs652921 and G carriers (TG/GG) of rs521845 had a higher DCM risk and CC homozygote of rs652921 had a worse DCM prognosis. These associations were still significant after adjustment for the Bonferroni correction. Conclusion: TAB2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0384

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