Comorbidities in elderly patients with glioblastoma: a field-practice study-Reference-Cited by-同舟云学术

Comorbidities in elderly patients with glioblastoma: a field-practice study

Published:2019-03 Issue:8 Volume:15 Page:841-850
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Villani Veronica¹,Tanzilli Antonio¹,Telera Stefano M²,Terrenato Irene³,Vidiri Antonello⁴,Fabi Alessandra⁵,Zucchella Chiara⁶,Carapella Carmine M²,Marucci Laura⁷,Casini Beatrice⁸,Carosi Mariantonia⁸,Oppido Piero M²,Pace Andrea¹

Affiliation:

1. Neuro-Oncology Unit, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

2. Division of Neurosurgery, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

3. Biostatistic Unit, Scientific Direction, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

4. Service of Neuroradiology, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

5. Division of Medical Oncology, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

6. Neurology Unit, ‘Azienda Ospedaliera Universitaria Integrata’ Piazzale Aristide Stefani 1, 37126 Verona, Italy

7. Radiotherapy Unit, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

8. Division of Neuropathology, ‘Regina Elena’ National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy

Abstract

Aim: This single-center study evaluated the effect of comorbidities on progression-free and overall survival in elderly patients with glioblastoma multiforme (GBM). Patients & methods: Comorbid conditions were identified in each patient with the modified version of the cumulative illness rating scale (CIRS). Results: Total of 118 patients with GBM were enrolled. An age of >75 years at diagnosis, high CIRS, comorbidity index and performance status play a predictive role on survival. Conclusion: Comorbidities play an important prognostic role in elderly patients with GBM, a factor too often neglected in clinical practice. If the prognostic role of comorbidity measured by CIRS on outcome will be confirmed, it would be interesting to add it in the algorithm for treatment choice in elderly GBM patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0524

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