Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?-Reference-Cited by-同舟云学术

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Published:2024-03-06 Issue:5 Volume:13 Page:1512
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Pasqualetti Francesco¹^ORCID,Gabelloni Michela²^ORCID,Faggioni Lorenzo³^ORCID,Aquaro Giovanni Donato³^ORCID,De Vietro Fabrizio³,Mendola Vincenzo³,Spina Nicola³,Frey Jessica³,Montemurro Nicola⁴^ORCID,Cantarella Martina¹,Caccese Mario⁵^ORCID,Gadducci Giovanni¹,Giannini Noemi¹,Valenti Silvia¹,Morganti Riccardo⁶^ORCID,Ius Tamara⁷^ORCID,Caffo Maria⁸^ORCID,Vergaro Giuseppe⁹¹⁰,Cosottini Mirco¹¹,Naccarato Antonio Giuseppe¹²^ORCID,Lombardi Giuseppe⁵^ORCID,Bocci Guido¹³^ORCID,Neri Emanuele³^ORCID,Paiar Fabiola¹

Affiliation:

1. Radiation Oncology Unit, Azienda Ospedaliero Universitaria Pisana, 56123 Pisa, Italy

2. Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy

3. Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy

4. Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana, 56123 Pisa, Italy

5. Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy

6. Section of Statistics, University Hospital of Pisa, 56124 Pisa, Italy

7. Neurosurgery Unit, Head-Neck and NeuroScience Department, University Hospital of Udine, 33100 Udine, Italy

8. Department of Neurosurgery, University of Messina, 98122 Messina, Italy

9. Interdisciplinary Center for Health Sciences, Scuola Superiore Sant’Anna, 56127 Pisa, Italy

10. Cardiology Division, Fondazione Toscana Gabriele Monasterio, 56127 Pisa, Italy

11. Department of Neuroradiology, University of Pisa, 56126 Pisa, Italy

12. Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy

13. Department of Clinical and Experimental Medicine, Clinical Pharmacology, University of Pisa, 56126 Pisa, Italy

Abstract

Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy. Results: We analysed 50 GBM patients. At the univariate analysis, methyl-guanine-methyltransferase gene (MGMT) promoter methylation (p = 0.048), gross total tumour resection (p = 0.017), and calcium score (p = 0.011) were significant prognostic predictors in patients with GBM. These three variables also maintained statistical significance in the multivariate analysis. Conclusions: the ICA calcium score could be a promising prognostic biomarker in GBM patients.

Funder

AIRC and the Research and Innovation Programme

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/5/1512/pdf

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