Active diffusion of nanoparticles of maternal origin within the embryonic brain-Reference-Cited by-同舟云学术

Active diffusion of nanoparticles of maternal origin within the embryonic brain

Published:2016-10 Issue:19 Volume:11 Page:2471-2481
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Yuryev Mikhail¹,Ferreira Mónica PA²,Balasubramanian Vimalkumar²,Correia Alexandra MR²,Mäkilä Ermei M³,Jokinen Ville⁴,Andriichuk Liliia¹,Kemell Marianna⁵,Salonen Jarno J³,Hirvonen Jouni T²,Santos Hélder A²,Rivera Claudio¹⁶

Affiliation:

1. Neuroscience Center, University of Helsinki, FI-00014 Helsinki, Finland

2. Division of Pharmaceutical Chemistry & Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland

3. Laboratory of Industrial Physics, Department of Physics & Astronomy, University of Turku, FI-20014 Turku, Finland

4. Aalto University, School of Chemical Technology, FI-02150 Espoo, Finland

5. Department of Chemistry, University of Helsinki, PO Box 55, FI-00014 Helsinki, Finland

6. Institut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale Unité 901, 13009 Marseille, France Aix-Marseille Université, Unité Mixte de Recherche 901, 13273 Marseille, France

Abstract

Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2016-0207

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