Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells-Reference-Cited by-同舟云学术

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Published:2021-08 Issue:20 Volume:16 Page:1763-1773
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Sharma Ankur¹²^ORCID,Hawthorne Susan²,Jha Saurabh Kumar³,Jha Niraj Kumar³^ORCID,Kumar Dhruv⁴,Girgis Samuel⁵,Goswami Vineet Kumar⁶,Gupta Gaurav⁷,Singh Sachin⁸,Dureja Harish⁹,Chellappan Dinesh Kumar¹⁰^ORCID,Dua Kamal¹¹^ORCID

Affiliation:

1. Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Uttar Pradesh, 201310, India

2. School of Pharmacy & Pharmaceutical Sciences, Saad Centre for Pharmacy & Diabetes, Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK

3. Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Uttar Pradesh, 201310, India

4. Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida, Uttar Pradesh, 201301, India

5. School of Pharmacy, University of Sunderland, Chester Road, Sunderland, SR1 3SD, UK

6. Department of Biological Sciences, School of Basic & Applied Sciences, G.D. Goenka University, Education city, Sohna Road, Gurugram, Haryana, 122103, India

7. School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 302017, India

8. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144402, India

9. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India

10. Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, 57000, Malaysia

11. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia

Abstract

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0066

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