Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform

Author:

Stacey Glyn N1,Andrews Peter W2,Barbaric Ivana2,Boiers Charlotta34,Chandra Amit5,Cossu Giulio6,Csontos Lynn7,Frith Thomas JR2,Halliwell Jason A2,Hewitt Zoe2,McCall Mark8,Moore Harry D2,Parmar Malin910,Panico M Beatrice11,Pisupati Venkat1213,Shichkin Valentin P1415,Stacey Alison R6,Tedesco Francesco S1617,Thompson Oliver2,Wagey Ravenska18

Affiliation:

1. International Stem Cell Banking Initiative, 2 High Street, Barley, Hertfordshire SG8 8HZ, UK

2. Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK

3. Department of Cancer Biology, University College London, London, WC1E 6DD, UK

4. Cancer Institute, University College London, London, WC1E 6DD, UK

5. Yposkesi, 91100 Corbiel-Essonnes, France

6. Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, M13 9PL, UK

7. STEMCELL Technologies, Waterbeach, CB25 9TL, UK

8. Centre for Biological Engineering, Loughborough University, Loughborough, LE11 3TU, UK

9. Developmental & Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, S221 84, Sweden

10. Lund Stem Cell Center, Lund University, Lund, S221 84, Sweden

11. Medicines & Healthcare products Regulatory Agency, London, E14 4PU, UK

12. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

13. Wellcome Trust – Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 0PY, UK

14. Research Centre of Immunology & Biomedical Technologies, Open International University of Human Development Ukraine, Kyiv 03115, Ukraine

15. Bienta Ltd, 78 Chervonotkatska Str., Kyiv 02094, Ukraine

16. Department of Cell & Developmental Biology & Great Ormond Street Institute of Child Health, University College London, WC1E 6DE, UK

17. The Dubowitz Neuromuscular Centre, Greta Ormond Street Institute of Child Health, University College London, WC1N 1EH, London, UK

18. STEMCELL Technologies, Vancouver, BC, V6A 1B6, Canada

Abstract

Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, biomanufacturing and regulation, to discuss key issues in assuring appropriate manufacturing conditions for delivery of effective and safe products from these cell types. This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Reference36 articles.

1. UK Regenerative Medicine Platform. (2018). www.ukrmp.org.uk/hubs/.

2. PluriMes. (2019). www.plurimes.eu.

3. Mucin-Inspired Thermoresponsive Synthetic Hydrogels Induce Stasis in Human Pluripotent Stem Cells and Human Embryos

4. EU Tissue and Cells Directives. Directive 2004/23/EC of the European Parliament and the Council of 31 March 2004 on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells. L102, 48e58 (2004).

5. European Commission (2004). http://ec.europa.eu/health//sites/helath/files/files/eudralex/vol-1/dir_2004_27_en.pdf.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3