DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study-Reference-Cited by-同舟云学术

DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study

Published:2021-05 Issue:9 Volume:13 Page:653-666
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Chilunga Felix P¹^ORCID,Henneman Peter²^ORCID,Venema Andrea²,Meeks Karlijn AC³^ORCID,Gonzalez Juan R⁴^ORCID,Ruiz-Arenas Carlos⁴^ORCID,Requena-Méndez Ana⁴⁵^ORCID,Beune Erik¹^ORCID,Spranger Joachim⁶^ORCID,Smeeth Liam⁷^ORCID,Bahendeka Silver⁸^ORCID,Owusu-Dabo Ellis⁹^ORCID,Klipstein-Grobusch Kerstin¹⁰¹¹^ORCID,Adeyemo Adebowale³^ORCID,Mannens Marcel MAM²^ORCID,Agyemang Charles¹^ORCID

Affiliation:

1. Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

2. Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

3. Center for Research on Genomics & Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20894, USA

4. Barcelona Institute for Global Health (ISGlobal, University of Barcelona), 08003 Barcelona, Spain

5. Department of Global Public Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden

6. Department of Endocrinology, Diabetes & Metabolism, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany

7. Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, 1E 7HT, UK

8. Department of Medicine, MKPGMS-Uganda Martyrs University, 8H33+5M Kampala, Uganda

9. School of Public Health, Kwame Nkrumah University of Science & Technology, MCFH+R9 Kumasi, Ghana

10. Julius Global Health, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands

11. Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of The Witwatersrand, 2193 Johannesburg, South Africa

Abstract

Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2–4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.

Funder

FP7 Health,

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0329

Reference54 articles.

1. Organisation for Economic Co-operation and Development. International Migration Outlook 2019 (2019). https://www.oecd-ilibrary.org/content/publication/c3e35eec-en

2. Global Burden of Cardiovascular Diseases

3. Obesity and type 2 diabetes in sub-Saharan Africans – Is the burden in today’s Africa similar to African migrants in Europe? The RODAM study

4. Cancer risk diversity in non-western migrants to Europe: An overview of the literature

5. Migration and schizophrenia

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