Brain stimulation in Huntington's disease

Author:

Hartmann Christian Johannes12,Groiss Stefan Jun12,Vesper Jan3,Schnitzler Alfons12,Wojtecki Lars12

Affiliation:

1. Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany

2. Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany

3. Department of Neurosurgery, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany

Abstract

Huntington's disease (HD) is a hereditary neurodegenerative disorder which is associated with severe disturbances of motor function, especially choreatic movements, cognitive decline and psychiatric symptoms. Various brain stimulation methods have been used to study brain function in patients with HD. Moreover, brain stimulation has evolved as an alternative or additive treatment option, besides current symptomatic medical treatment. This article summarizes the results of brain stimulation to better understand the characteristics of cortical excitability and plasticity in HD and gives a perspective on the therapeutic role for noninvasive and invasive neuromodulatory brain stimulation methods.

Publisher

Future Medicine Ltd

Subject

Clinical Neurology

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Translational Approach Using Advanced Therapy Medicinal Products for Huntington's Disease;Current Reviews in Clinical and Experimental Pharmacology;2024-05-23

2. The Use of Various Neurostimulators in Therapy of Neurodegenerative Disorders – A Survey;2022 Progress in Applied Electrical Engineering (PAEE);2022-06-27

3. Transcranial magnetic stimulation in animal models of neurodegeneration;Neural Regeneration Research;2022

4. Management of Motor Symptoms in Dementia Disorders;Management of Patients with Dementia;2021

5. Medical, Surgical, and Genetic Treatment of Huntington Disease;Neurologic Clinics;2020-05

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