Therapeutic implications of cancer stem cells in prostate cancer

Author:

Banerjee Pinaki,Kapse Prachi,Siddique Shehnaz,Kundu Moumita,Choudhari Jasoda,Mohanty Varshasnata,Malhotra Diksha,Gosavi Suresh W.,Gacche Rajesh N.,Kundu Gopal C.ORCID

Abstract

Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.

Publisher

China Anti-cancer Association

Subject

Cancer Research,Oncology

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