Kırım Kongo Kanamalı Ateşi Virüsünün Tokat/Türkiye’de PCR Tanısı, Epidemiyolojik ve Klinik Verileri

Abstract

Objectives: To contribute to case management algorithms and guidelines by evaluating the clinical symptoms, laboratory data, risk factors and mortality rates of patients admitted to health institutions with tick bite in Tokat. Methods: The virus determination was made from the blood by conventional PCR in 141 patient. Epidemiological data such as socio-demographic variables and risk factors were compared with clinical symptoms, biochemical and hematological parameters. Results: Of the patients, 83 (58.9%) were male, 84(59.6%) were positive. Five patients (5.95%) died in the PCR-positive group. Fever and tick contact history rates was found to be significantly higher in the PCR positive patients than the PCR negative group. Thrombocytopenia, leukopenia, aspartate transaminase (AST) elevation were found to be significantly higher in PCR positive patients. Despite the mean alanine transferase (ALT) was not significantly higher, the increase in the number of patients exceeding the reference range was found to be significantly higher in PCR-positive group (p