Affiliation:
1. University of São Paulo, Brazil
Abstract
A major role of the serotonergic system has been hypothesized in the pathogenesis of schizophrenia, mostly based on the evidence of action of atypical antipsychotics. Disturbances of serotonergic pathways have been implicated in the etiology of schizophrenia. The aim of this study was to investigate the association between schizophrenia and the G861C polymorphism in the 5-HT1Dbeta autoreceptor gene. There was conducted a case-control analysis in a sample of 196 schizophrenic patients and 143 gender, age and ethnic matched controls. No statistically differences were found in allelic or genotypic distributions between cases and controls. Thus, the results do not support an association of the G861C polymorphism in the 5-HT1Dbeta autoreceptor gene with schizophrenia in the studied sample.
Subject
Neurology,Neurology (clinical)
Reference22 articles.
1. Seminars in psychiatric genetics;McGuffin P,1994
2. Molecular genetics of schizophrenia: past, present and future;Prasad S;J Biosci,2002
3. Neurochemistry and neuropharmacology of schizophrenia;Stahl SM,1987
4. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophenics;Joyce JN;Neuropsychopharmacology,1993
5. Serotonin-dopamine interaction and its relevance to schizophrenia;Kapur S;Am J Psychiatry,1996
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献