Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia

Author:

Bertola Vivian1,Cordeiro Quirino1,Zung Stevin1,Miracca Elisabete Cristina1,Vallada Homero1

Affiliation:

1. University of São Paulo, Brazil

Abstract

Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. Disturbances of serotonergic brain pathways have been implicated in the pathophysiology of schizophrenia. Some studies have suggested that the efficacy of atypical antipsychotics on schizophrenia treatment may be related to the serotonin 2A receptor (5-HT2A), and that serotonergic drugs may induce psychotic symptoms. Thus, the aim of this study was to investigate the association between the C516T polymorphism and schizophrenia in a Brazilian population composed by 246 patients and 315 healthy matched controls in a case-control approach. No statistically differences were observed in allelic (chi2=1.77, 1d.f., p=0.18) or genotypic (chi2=1.69, 2d.f., p=0.42) distributions between cases and controls. The results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in our Brazilian sample.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Reference35 articles.

1. The genetic basis of schizophrenia;McGuffin P;Lancet,1995

2. An update on the genetics of schizophrenia;Norton N;Curr Opin Psychiatry,2006

3. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice;Gingrich, JA;Psychopharmacology,2001

4. Serotonin model of schizophrenia: emerging role of glutamate mechanisms;Aghajanian GK;Brain Res Rev,2000

5. Neurochemistry and neuropharmacology of schizophrenia;Stahl SM,1987

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3