Selective hypothermia: an experimental study on traumatic brain injury in rats

Author:

Dvilevicius Amylcar Edemilson1,Prandini Mirto Nelso1

Affiliation:

1. Universidade Federal de São Paulo, Brazil

Abstract

OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference30 articles.

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4. Mechanism of ventricular fibrillation in hypothermia;Covino BG;Circ Res,1962

5. The detrimental effects of prolonged hypothermia and rewarming in the dog;Steen PA;Anesthesiology,1980

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