Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis

Author:

Marques Vanessa Daccach1,Passos Giordani Rodrigues dos2,Mendes Maria Fernanda1,Callegaro Dagoberto1,Lana-Peixoto Marco Aurélio3,Comini-Frota Elizabeth Regina4,Vasconcelos Cláudia Cristina Ferreira5,Sato Douglas Kazutoshi2,Ferreira Maria Lúcia Brito6,Parolin Mônica Koncke Fiuza7,Damasceno Alfredo8,Grzesiuk Anderson Kuntz9,Muniz André10,Matta André Palma da Cunha11,Oliveira Bianca Etelvina Santos de12,Tauil Carlos Bernardo13,Maciel Damacio Ramón Kaimen14,Diniz Denise Sisteroli15,Corrêa Eber Castro16,Coronetti Fernando17,Jorge Frederico M. H.1,Sato Henry Koiti18,Gonçalves Marcus Vinícius Magno19,Sousa Nise Alessandra de C.20,Nascimento Osvaldo J. M.11,Gama Paulo Diniz da21,Domingues Renan22,Simm Renata Faria1,Thomaz Rodrigo Barbosa23,Morales Rogério de Rizo24,Dias Ronaldo Maciel25,Apóstolos-Pereira Samira dos1,Machado Suzana Costa Nunes26,Junqueira Thiago de Faria27,Becker Jefferson28

Affiliation:

1. Universidade de São Paulo, Brasil

2. Pontifícia Universidade Católica do Rio Grande do Sul, Brasil

3. Universidade Federal de Minas Gerais, Brasil

4. Universidade José do Rosário Vellano, Brasil

5. Universidade Federal do Estado do Rio de Janeiro, Brasil

6. Hospital da Restauração, Brasil

7. Clínica Gonçalves Dias, Brasil

8. Universidade de Campinas, Brasil

9. Clínica Privada, Brasil

10. Hospital São Rafael, Brasil

11. Universidade Federal Fluminense, Brasil

12. Fundação Centro Integrado de Apoio ao Portador de Deficiência, Brazil

13. Universidade de Brasília, Brasil; Universidade Católica de Brasília, Brasil

14. Santa Casa de Misericórdia de Londrina, Brasil

15. Universidade Federal de Goiás, Brasil

16. Clínica de Neurologia e Endocrinologia, Brasil

17. Universidade Estadual Paulista, Brasil

18. Instituto de Neurologia de Curitiba, Brasil

19. Universidade da Região de Joinville, Brasil

20. Universidade Federal do Amazonas, Brazil

21. Pontifícia Universidade Católica de São Paulo, Brasil

22. Senne Líquor Diagnóstico, Brasil; Hospital Cruz Azul, Brasil; Faculdade São Leopoldo Mandic, Brasil

23. Hospital Israelita Albert Einstein, Brasil

24. Universidade Federal de Uberlândia, Brasil

25. Hospital de Base do Distrito Federal, Brasil

26. Imperial Hospital de Caridade, Brasil

27. Escola Bahiana de Medicina e Saúde Pública, Brasil

28. Pontifícia Universidade Católica do Rio Grande do Sul, Brasil; Universidade Federal Fluminense, Brasil

Abstract

ABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference125 articles.

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3. Secretaria de Atenção à Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Portaria Conjunta Nº 10, de 2 de abril de 2018. Aprova o protocolo clínico e diretrizes trapêuticas da esclerose múltipla,2018

4. [Recommendations for the use of immunomodulatory drugs in multiple sclerosis: the BCTRIMS consensus];Tilbery CP;Arq Neuropsiquiatr,2000

5. [The BCTRIMS Expanded Consensus on treatment of multiple sclerosis: I. The evidences for the use of immunosuppressive agents, plasma exchange and autologous hematopoietic stem cell transplantation];Callegaro D;Arq Neuropsiquiatr,2002

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