Effect of microalga Spirulina platensis (Arthrospira platensis) on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia

Author:

Bertolin Telma Elita1,Pilatti Dayane2,Giacomini Ana Cristina Vendrametto Varrone2,Bavaresco Caren Serra2,Colla Luciane Maria1,Costa Jorge Alberto Vieira3

Affiliation:

1. Centro de Pesquisa em Alimentação, Brasil

2. Universidade de Passo Fundo, Brasil

3. Universidade Federal do Rio Grande, Brasil

Abstract

Studies have been conducted on microalga Spirulina platensis (Arthrospira platensis) due to its therapeutic potential in several areas, including the capacity for preventing and decreasing the damages caused by hyperlipidemia and the antioxidant activity. The aim of the study was to evaluate the effect of microalga Spirulina platensis on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia during 60 days. The measurement of hippocampus lipoperoxidation did not demonstrate significant difference (p>0.05) when Spirulina platensis was added to hypercholesterolemic diet. The evaluation of lipid profile showed that the administration of the microalga in therapeutic and preventive ways led to a significant protective effect (p<0.05) from hypercholesterolemia.

Publisher

FapUNIFESP (SciELO)

Subject

Multidisciplinary

Reference23 articles.

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2. Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice;Blé-Castillo J. L.;Life Sciences,2002

3. Utilização da Spirulina platensis como inibidor da hipercolesterolemia experimental em coelhos;Colla L. M.,2002

4. Production of biomass and nutraceutical compounds by Spirulina platensis under different temperature and nitrogen regimes;Colla L. M.;Bioresource Technology,2007

5. Simultaneous cultivation of Spirulina platensis and the toxigenic cyanobacteria Microcystis aeruginosa;Costa J. A. V.;Zeitschrift Für Naturforschung C-A Journal of Biosciences,2006

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